Scientists from Tyumen State University (Tyumen State University) together with their Russian colleagues have found a universal natural antibiotic overcoming the resistance of pathogens to medicines. The text of the study was published in the journal Applied Biochemistry and Microbiology.
The authors argue that the found substance will help to effectively fight most infectious diseases of humans and animals caused by bacteria and fungi.
According to the scientists of the University, one of the tasks of pharmacology is to find natural antibiotics capable of fighting with microorganisms that have multiple (multi-drug resistant, MDR) or absolute (extreme-drug resistant, XDR) resistance to antibiotics available on the market.
The researchers from Tyumen State University were the first in the world to demonstrate the unique ability of Emericellopsis alkaline, a peptide of Emericellopsis A extracted from the alkalophilic micellopsis. According to experts, the substance inhibits the bacteria’s ability to form biofilms, which makes these pathogens resistant to antibiotics.
As the authors of the work explained, the main therapeutic feature of the studied substance is the universality of exposure. Not only MDR- and XDR-form of bacteria are defenseless before americillipsin A, but also almost any pathogenic eukaryotes, such as micellar fungi and yeast.
“Emericillipsin A acts on eukaryotes and prokaryotes through various molecular mechanisms. Eukaryotes – fungi and tumor cells – die due to the destruction of their cell membrane by a peptide, and virulence of prokaryotes is suppressed by preventing the formation of biofilms,” – said a senior researcher of the laboratory of antimicrobial resistance of X-BIO at Tyumen State University Evgeny Rogozhin.
As the scientists noted, among the pathologies, which will allow fighting with emericillipsin A, are tumors, as well as all kinds of bacterial and fungal infections.
Emericillipsin A, according to specialists of Tyumen State University, is promising both as an independent therapeutic agent and as an element of complex drugs. Therapy can be performed either through injections or locally – through direct treatment of affected tissues.
The study was conducted in close cooperation with colleagues from the G.F. Gauze Research Institute for Research on New Antibiotics, the Central Research Institute of Epidemiology of Rospotrebnadzor, and the G.F. Gauze Institute of Bioorganic Chemistry. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
In the future, the team of scientists intends to move from working with cell models to laboratory testing of the preparation.