The French scientists informed the international community about the successful use of a combination of several existing drugs for treatment coronaviruses infection COVID-19. The results were published in the official journal of the International Society of antimicrobial chemotherapy International Journal of Antimicrobial Agents.
It should be noted that clinical studies were conducted on the basis of the infectious hospital at Marseille University. The control group for treatment was recruited in Marseilles, Nice, Avignon, and Briancon, i.e. in the South of France, near the Italian border.
It is clarified that the actions of hydroxychloroquine and azithromycin were effective against the coronavirus, which is now there are no special preparations. Therefore, against the coronavirus used combinations of existing drugs used against other infectious diseases to study their effects.
The study was built around two drug groups. The first is antimalaria drugs chloroquine and hydroxychloroquine. The second group was presented a drug Ramdev Pir drug with broad anti-viral effects. This drug inhibits viral replication by premature termination of RNA transcription.
All three of the drug has shown activity against the coronavirus. In China, chloroquine is already in use as antiviral agents for the treatment of coronavirus infection. But for the official introduction of the mentioned drugs in medical practice, it was necessary to conduct clinical trials. The French held them. Rather, it is the first such trials that have examined the effectiveness of these drugs against COVID-19.
The researchers explained that the clinical trials took 36 adults (over 18 years). And, as with symptoms of coronavirus infection, and an asymptomatic carrier state where the virus SARS-CoV-2 was detected in the sample of the nasopharynx.
In the first group of 16 people, there were those who did not want to take these drugs, they were prescribed symptomatic treatment and antibiotics to prevent bacterial superinfection (simplified – when in the lungs instead of Albiol grow mushrooms).
The second group was 14 people, which within ten days was orally administered 200 mg of hydroxychloroquine sulfate three times a day.
In the third group had 6 people, they are in addition of hydroxychloroquine to prevent bacterial superinfection first two days were given 500 mg of azithromycin, and then another four days at 250 mg. after 5 days these people have tests COVID-19 were negative, which was confirmed later. This indicates that all these patients, being in a small group fully recovered during this time. Moreover, one woman who received only hydroxychloroquine and was not cured started taking azithromycin on the eighth day, and on a ninth day her coronavirus tests were already negative. At the same time, scientists say that since the test group was small, it is necessary to conduct large-scale clinical trials to confirm the results.