Scientists at the University of Pittsburgh School of Medicine in the U.S. have developed a new method for obtaining powerful fragments of antibodies against coronavirus SARS-CoV-2 from the body of lamas. These molecules may become the basis for the development of inhalation drugs that prevent and treat COVID-19. The article has been published in the journal Science.
The researchers immunized the lamas with a fragment of SARS-CoV-2 spike protein (S-protein), so that two months later, the animal’s immune system produced mature nonetheless against the virus. With the help of mass spectrometry, scientists identified the nanobodies that bind most strongly to the SARS-CoV-2. Testing revealed that only a fraction of the antibody nanogram could save millions of cells from infection with coronavirus.
The new nonetheless are the most effective antibodies among the therapeutic antibodies against the SARS-CoV-2 and are hundreds and thousands of times more effective than other lamp nanobodies detected by the phage display method.
Nano tells can stay at room temperature for six weeks and carry the transformation into an aerosol to deliver the drug directly to the lungs. Since SARS-CoV-2 is a respiratory virus, nanoshells can bind to it in the respiratory system before the pathogen can cause harm.